Evidence OHDSI seeks to generate from
observational data
• Clinical characterization:
– Natural history: Who are the patients who have diabetes?
Among those patients, who takes metformin?
– Quality improvement: what proportion of patients with
diabetes experience disease-related complications?
• Population-level estimation
– Safety surveillance: Does metformin cause lactic acidosis?
– Comparative effectiveness: Does metformin cause lactic
acidosis more than glyburide?
• Patient-level prediction
– Given everything you know about me and my medical
history, if I start taking metformin, what is the chance that I
am going to have lactic acidosis in the next year?